Use of Selenium-containing Heterocyclic Compounds as a Means of Protecting Paint and Varnish Materials from Microbiological Damage

It was stated that the investigated selenium-containing heterocyclic compounds possess fungicidal activity. The values of the minimum inhibitory concentrations of these compounds for the most active micromycete-destructors of industrial and building materials were determined. The dependence of biocidal activity on the structure of the test compounds was revealed. It is shown that these compounds impart to the non-inflexible paint and varnish materials the properties of mushroom resistance and fungicidal properties, which makes it possible to use them as biocidal additives to protect paint and varnish materials from bio damage caused by microscopic fungi. A study was made of the ecological and toxicological characteristics of these compounds, using as a test organism the cultures of zeodiodaphynia and algae. Threshold concentrations of these compounds have been established.

1. Сухаревич В.И. Защита от биоповреждений, вызываемых грибами. СПб., ЭЛБИ—СПб, 2009. 207 с.

2. Pekhtasheva E., Neverov A., Kubica S., Zaikov G. Classification of biodamages, evaluation and protection methods. Journal of Chemistry & Chemical Technology. 2012. V. 6. № 4. Р. 459—472.

3. Тресконова К. Значение биоцидов в производстве современных лакокрасочных материалов. Лакокрасочные материалы и их применение. 2003. № 2—3. С. 20—22.

4. Яковлев А.Б. Эпидермодермальные микозы кожи в практике дерматолога. Лечащий Врач. 2012. № 5. С. 53—56.

5. Еремеева К.В. Микозы в оториноларингологии: диагностика, профилактика, лечение. Медицинский совет. 2016. № 18. С.14—17.

6. Вундер Т. Плёночные биоциды для фасадных покрытий: новые решения на базе известных активных веществ. Лакокрасочные материалы и их применение. 2008. № 4. С. 16—24.

7. Вуд П. Фунгициды и альгициды для наружных покрытий на Российском рынке. Лакокрасочные материалы и их применение. 2009. №3. С. 22—25.

8. Chassot F., Venturini T.P., Piasentin F.B., Santurio J.M., Svidzinski T.I., Alves S.H. Antifungal activities of diphenyl diselenide and ebselen against echinocandin-susceptible and-resistant strains of Candida parapsilosis. New Microbiol. 2016. V. 39. P. 301—303.

9. Venturini T.P., Chassot F., Loreto Е.S., Keller J.T., Azevedo M.I., Zeni G., Alves S.H. Antifungal activities of diphenyl diselenide and ebselen alone and in combination with antifungal agents against Fusarium spp. Sabouraudia. 2016. V. 54. Iss. 5. P. 550—555.

10. Thangamani S., Eldesouky H.E., Mohammad H., Pascuzzi P.E., Avramova L., Hazbun T.R., Seleem M.N. Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells. Biochimica et Biophysica Acta (BBA)-General Subjects. 2017. V. 1861. Iss. 1. P. 3002—3010.

11. Żesławska E., Korona-Głowniak I., Szczesio M., Olczak A., Żylewska A., Tejchman W., Malm A. Structural analysis and antimicrobial activity of 2 [1H]-pyrimidinethione/selenone derivatives. Journal of MolecularStructure. 2017. V. 1142. P. 261—266.

12. Mautner H., Chu S.H., Lee C.M. Studies of 2-selenopyridine and related compounds. J Org Chem. 1962. V. 27. P. 3671—3673.

13. Arvanitis G.M., Berardini M.E., Allardice D., Dumas P.E. Structure of bis(2-pyridine-N-oxide) diselenide and its formation from tetraphenylantimony(V)selenopyridine-N-oxide. J Chem Crystal. 1994. V. 24. Iss. 7. P. 421—423.

14. Wiegand I., Hilpert K., Hancock R.E. Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nat Protoc. 2008. V. 3. Iss. 2. P. 163—175.

15. Андреева Е.И. Методические испытания по определению фунгицидной активности новых соединений. Черкассы, НИИТЭХИМ, 1984. 34 с.

16. Кобзарь А.И. Прикладная математическая статистика. М., Физматлит, 2006. 816 с.